Biomolecular structures & interactions
The normal function of cells, tissues, and organs, and thus the maintenance of a healthy organism, requires a complex interplay of biomolecular interactions. Many disruptions of these interactions are associated with a variety of diseases. Thus, the elucidation of molecular structures and the resulting function of proteins, enzymes, cell membranes and lipid aggregates as well as their molecular interactions play a crucial role for the fundamental understanding of (patho-)physiological processes and the development of new therapeutic approaches. This includes, for example, highly specific active agents that have been specifically tailored to act on pathological-structural changes.
Within BioHealth, the research area "Biomolecular structures & interactions" studies biomolecular interactions, using a range of experimental and computational methods from the fields of integrative structural biology and biophysics. Among them, microscopic techniques, such as classical light/fluorescence microscopy and cryoelectron microscopy (cryoEM), as well as protein crystallography, nuclear magnetic resonance spectroscopy, (single molecule) fluorescence spectroscopy, X-ray and neutron small angle scattering, light scattering, calorimetry, chromatography, microfluidics, and quantum chemical and molecular dynamics simulations are used.
Currently, we are conducting research on the following topics:
- Structure-function relationships of proteins involved in intracellular and intravascular lipid metabolism, which are important for both energy balance and intercellular communication.
- Structure-based development of inhibitors of lipases from human pathogenic bacteria.
- Structure and function of proteins involved in ribosome biogenesis, particularly AAA-ATPases and RNA helicases.
- Structural determinants of enzyme properties, both to design enzymes with specific properties and to predict enzyme functions.
- Structural characterization of proteins and lipids of the bacterial cell membrane for the development of membrane-specific drugs.
- Functions of eukaryotic plasma membranes, particularly lipid asymmetry and its loss in cancer cells, which enables - among other things - the development of highly specific antitumor peptides.
- Interactions of pharmacologically important membrane receptors - G-protein-coupled receptors and receptor tyrosine kinases - with natural ligands, drugs and antibodies.
- Structure determination of major allergens for mechanistic elucidation of allergic diseases.
Biomolecular structures & interactions Team
Ao.Univ.-Prof. Mag. Dr. Helmut Bergler
Phone:+43 316 380 - 5629
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-7724-309X
Web: https://molekularbiologie.uni-graz.at/de/arbeitsgruppen-bergler-pertschy/
Mag. Dr.rer.nat. Christian Gruber
Phone:+43 316 380 - 5466
Location:Institut für Molekulare Biowissenschaften
Opentimes:Montag 17:00-18:00 (nach Voranmeldung)
ORCID iD: ORCID iD: 0000-0003-0214-449X
Web: https://molekularbiologie.uni-graz.at/en/strukturbiologie/
Univ.-Prof. Mag. Dr.rer.nat. Karl Gruber
Phone:+43 316 380 - 5417
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-3485-9740
Web: https://molekularbiologie.uni-graz.at/en/strukturbiologie/
Assoz. Prof. Priv.-Doz. Dr.rer.nat. Melanie Hall
Phone:+43 316 380 - 5479
Location:Institut für Chemie
ORCID iD: ORCID iD: 0000-0003-4539-1992
Web: http://biocatalysis.uni-graz.at/
Dipl.-Ing. Dr.techn. BSc Bettina Halwachs-Wenzl
Phone:+43 316 380 - 5387
Location:Institut für Pharmazeutische Wissenschaften
ORCID iD: ORCID iD: 0000-0002-7082-9346
Ass.-Prof. Dipl.-Ing. Dr.techn. Jürgen Hartler
Phone:+43 316 380 - 5382
Location:Institut für Pharmazeutische Wissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-1095-6458
Univ.-Prof. Dr.rer.nat. Sandro Manuel Keller
Phone:+43 316 380 - 4987
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0001-5469-8772
Ao.Univ.-Prof. Mag. Dr.rer.nat. Walter Keller
Phone:+43 316 380 - 5423
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0002-2261-958X
Ao.Univ.-Prof. Dr.phil. Guenther Koraimann
Phone:+43 316 380 - 5626
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-8937-3027
Web: http://homepage.uni-graz.at/de/guenther.koraimann/
Univ.-Prof. Dipl.-Ing. Dr.techn. Wolfgang Kroutil
Phone:+43 316 380 - 5350
Location:Institut für Chemie
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-2151-6394
Web: https://biocatalysis.uni-graz.at
Mag. Dr.rer.nat. Nermina Malanovic
Phone:+43 316 380 - 4981
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0002-2903-9369
Assoz. Prof. Mag. Dr.rer.nat. Monika Oberer
Phone:+43 316 380 - 5431
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung (Email oder Telefon)
ORCID iD: ORCID iD: 0000-0003-2525-9513
Web: https://molekularbiologie.uni-graz.at/en/strukturbiologie/
PhD Isabel Oroz-Guinea
Phone:+43 316 380 - 8635
Location:Institut für Chemie
ORCID iD: ORCID iD: 0000-0001-6989-3597
Assoz. Prof. Dipl.-Ing. Dr.techn. Georg Pabst
Phone:+43 316 380 - 4989
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0003-1967-1536
Web: http://homepage.uni-graz.at/de/georg.pabst/
Ass.-Prof. Mag. Dr. Tea Pavkov-Keller
Phone:+43 316 380 - 5483
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0001-7871-6680
Priv.-Doz. Mag. Dr.rer.nat. Brigitte Pertschy
Phone:+43 316 380 - 1518
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0003-3558-0191
Web: https://molekularbiologie.uni-graz.at/de/arbeitsgruppen-bergler-pertschy/
Dipl.-Ing. Dr.rer.nat. Sabrina Riedl
Phone:+43 316 380 - 4982
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0002-2608-0753
Dr.rer.nat. Georg Steinkellner
Phone:+43 316 380 - 5466
Location:Institut für Molekulare Biowissenschaften
Opentimes:-
ORCID iD: ORCID iD: 0000-0001-7565-8868
Univ.-Prof. Dipl.-Ing. Dr.rer.nat. Ulrich Stelzl
Phone:+43 316 380 - 5397
Location:Institut für Pharmazeutische Wissenschaften
Opentimes:nach Vereinbarung (ext. 5365)
ORCID iD: ORCID iD: 0000-0003-2500-3585
Web: https://pharmazie.uni-graz.at/de/unsere-forschung/pharmazeutische-chemie/
Ao.Univ.-Prof. Mag. Dr.rer.nat. Klaus Zangger
Phone:+43 316 380 - 8673
Phone:+43 650 4009779
Location:Institut für Chemie
ORCID iD: ORCID iD: 0000-0003-1682-1594
Web: https://www.uni-graz.at/klaus.zangger
Assoz. Prof. Dipl.-Ing. Dr.techn. Dagmar Zweytick
Phone:+43 316 380 - 4988
Location:Institut für Molekulare Biowissenschaften
Opentimes:Dienstag 11:00 bis 12:00
ORCID iD: ORCID iD: 0000-0002-4766-7713