Fat Metabolism
Metabolic disturbances caused by excessively high calorie diets, lack of exercise or disturbed chronobiology can lead to a multimorbid state known as the metabolic syndrome. Associated conditions such as obesity, hypertension, cardiovascular diseases, type 2 diabetes and non-alcoholic fatty liver disease (NAFLD) affect hundreds of millions of people worldwide. Cancer patients also suffer from metabolic imbalances and impaired fat metabolism, which often lead to cachexia, a life-threatening emaciation that is characterized by lipid wasting.
The BioHealth research area "Energy & Lipid Metabolism" therefore focuses on the molecular mechanisms and (patho)physiological effects of fat or lipid metabolism, especially in the context of obesity, the main risk factor for metabolic syndrome and related diseases. A better understanding of the exact functioning of lipids and their metabolism in different organs, for example in the heart or the liver, and its influence on pathological changes makes it possible to design counterstrategies and therapeutic approaches against lipid-associated disease. For this purpose, different cellular and animal models are used within BioHealth. Collaborations with national and international medical universities enable us to conduct clinical trials.
Currently, we are conducting research on the following topics:
- Characterization of enzymes involved in lipid metabolism, in particular new lipases that enable cells and organs to utilize fat reserves.
- Development of inhibitors of the "adipose triglyceride lipase" (ATGL) for the treatment of fatty liver disease, cachexia and type 2 diabetes.
- The metabolism of the amino acids methionine and homocysteine in the context of metabolic syndrome, obesity and type II diabetes.
- The interplay between lipid metabolism and regulation of cell-protective autophagy.
- Inter-organ communication to regulate lipid metabolism, the role of lipids as signaling agents and the metabolism of complex lipids such as sterols.
- Physiological and molecular adaptations of lipid metabolism to extreme environmental conditions.
Fat metabolism team
Priv.-Doz. Dipl.-Ing. Dr.techn. Karin Athenstaedt
Phone:+43 316 380 - 1988
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0001-7198-3989
Univ.-Prof. Dr.rer.nat. Valery Bochkov
Phone:+43 316 380 - 5398
Location:Institut für Pharmazeutische Wissenschaften
ORCID iD: ORCID iD: 0000-0003-3043-1736
Dipl.-Ing. Dr.techn. Clemens Diwoky
Phone:+43 316 380 - 1506, 1966
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0001-7265-1142
Web: https://molekularbiologie.uni-graz.at/en/core-facility-mri/
Assoz. Prof. Dipl.-Biochem. Dr.rer.nat. Tobias Eisenberg
Phone:+43 316 380 - 1499
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0003-3559-1130
Web: https://molekularbiologie.uni-graz.at/de/labor-tobias-eisenberg/
Mag. Dr.rer.nat. Christian Gruber
Phone:+43 316 380 - 5466
Location:Institut für Molekulare Biowissenschaften
Opentimes:Montag 17:00-18:00 (nach Voranmeldung)
ORCID iD: ORCID iD: 0000-0003-0214-449X
Web: https://molekularbiologie.uni-graz.at/en/strukturbiologie/
Univ.-Prof. Mag. Dr.rer.nat. Karl Gruber
Phone:+43 316 380 - 5417
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-3485-9740
Web: https://molekularbiologie.uni-graz.at/en/strukturbiologie/
Assoz. Univ.-Prof. Mag. Dr.rer.nat. Guenter Haemmerle
Phone:+43 316 380 - 1910
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0001-9900-5896
Ass.-Prof. Dipl.-Ing. Dr.techn. Jürgen Hartler
Phone:+43 316 380 - 5382
Location:Institut für Pharmazeutische Wissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-1095-6458
Univ.-Prof. Dr.rer.nat. Ronald Kühnlein
Phone:+43 316 380 - 5504
Location:Institut für Molekulare Biowissenschaften
Opentimes:Sprechstunde nach vorheriger Anmeldung: Montags 11-12Uhr (optional auch über uniMEET)
ORCID iD: ORCID iD: 0000-0003-1448-4117
Web: https:// https://homepage.uni-graz.at/en/ronald.kuehnlein/
Assoz. Prof. Mag. Dr.rer.nat. Achim Lass
Phone:+43 316 380 - 1926
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung (tel. oder per E-mail)
ORCID iD: ORCID iD: 0000-0002-8190-7151
Web: https://molekularbiologie.uni-graz.at/en/research/areas-of-research/in-mammalian-cells/
Assoz. Prof. Mag. Dr.rer.nat. Monika Oberer
Phone:+43 316 380 - 5431
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung (Email oder Telefon)
ORCID iD: ORCID iD: 0000-0003-2525-9513
Web: https://molekularbiologie.uni-graz.at/en/strukturbiologie/
Ass.-Prof. Mag. Dr.rer.nat. Karina Preiß-Landl
Phone:+43 316 380 - 1965
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0003-0266-5973
Priv.-Doz. Mag. Dr.rer.nat. Franz Radner
Phone:+43 316 380 - 1921
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0003-3466-0181
Web: https://www.uni-graz.at/imbmwww
Mag. Dr.rer.nat. Gerald Rechberger
Phone:+43 316 380 - 1933
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-0071-317X
Web: https://molekularbiologie.uni-graz.at/de/massenspektrometrie/
Mag. Dr.rer.nat. Gabriele Schoiswohl
Phone:+43 316 380 - 5569
Location:Institut für Pharmazeutische Wissenschaften
ORCID iD: ORCID iD: 0000-0002-7346-2834
Mag. Dr.rer.nat. Renate Schreiber
Phone:+43 316 380 - 1907
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0002-3475-157X
Assoz. Prof. Mag. Dr.rer.nat. Martina Schweiger
Phone:+43 316 380 - 1908
Location:Institut für Molekulare Biowissenschaften
Opentimes:Donnerstag 9:00-10:00 oder nach Vereinbarung
ORCID iD: ORCID iD: 0000-0002-3419-1007
Priv.-Doz. Dr.rer.nat. Oksana Tehlivets
Phone:+43 316 380 - 1995
Location:Institut für Molekulare Biowissenschaften
ORCID iD: ORCID iD: 0000-0003-1650-5014
Web: http://yeast.uni-graz.at/
Mag. Dr.rer.nat. Heimo Wolinski
Phone:+43 316 380 - 5489, 8683
Location:Institut für Molekulare Biowissenschaften
Opentimes:by appointment.
ORCID iD: ORCID iD: 0000-0002-1583-6092
Web: https://homepage.uni-graz.at/de/heimo.wolinski/
Univ.-Prof. Dr.phil. Rudolf Zechner
Phone:+43 316 380 - 5028
Location:Dekanat der Naturwissenschaftlichen Fakultät
ORCID iD: ORCID iD: 0000-0001-5483-1182
Web: https://molekularbiologie.uni-graz.at
Assoz. Prof. Mag. Dr.rer.nat. Robert Zimmermann
Phone:+43 316 380 - 1914
Location:Institut für Molekulare Biowissenschaften
Opentimes:nach Vereinbarung per email
ORCID iD: ORCID iD: 0000-0002-7354-870X